Monday 25 May 2015

Pharmaceutical tablet compression punches and dies



Tablets are manufactured by compressing a formulation having a drug or drugs with excipients on stamping machine which are called tablet press or tablet compression machine. The machine is a critical element of producing oral solid dosage formulations. To form a tablet, a formulation having a drug is evaluated into a cavity created by punches and dies. After this, punches are pressed together with great pressure to fuse the matter together. In tabletcompression punches and dies system dies are used to give specific shape and size to the tablet and punches are used to compress the material such as drugs and drugs with excipients or granules within the dies. 

For tablet pressing, controlling the individual weight of tablets is critical. Two important factors which are difficult to control, but are essential for tablet’s bioavailability (the rate and degree at which a drug or a substance is absorbed into a living system) and clinical effect, are disintegration rate and tensile strength. Conventional tablet presses determine a tablet’s weight either by evaluating its variation in tablet height at pre-compression or the pressure at main compression. These procedures, however, pass over one major characteristic which is tensile strength. A tablet’s tensile strength controls drugs bioavailability and clinical effect, which are critical for any dosage form.

Punches and dies sets are available in different types such as Regular shape punch die set, irregular shapes punch die set, core rod tooling punch and die set, sealed groove punch and die set. Regular shape punch and die set consists of round, capsule, oval and geometric shapes. Usually, round shapes punch die sets are most commonly used by pharmaceutical and veterinary sector. These punch die sets are offered in different concavity, size and flat in plain or imprinted break line. Capsule punch die set aids you to form tablets of capsule shape. These types of sets are highly used in pharma and ayurvedic industries.

Oval shape punch die sets aids you to form oval or ellipse shape tablets. Usually oval shape punch die sets are used in ayurvedic as well as pharma industries. Geometric shape punch die sets are enable you to form tablets with different geometric shapes such as rectangular, square, triangular, rohmbus benzene etc. These punch die sets are highly applicable in the industries such as pharmaceutical, chemical, confectionery, industrial powder metallurgy etc. Irregular shape punch die sets are used to form tablets in different shapes such as animals, fruits, vehicle, part of human body, etc. These punch die sets find its applications in confectionery industries.

3 comments:

  1. Wow!!!
    It is really a nice blog with lots of informative stuff about Die and Punch, i really appreciate your research & knowledge. Nice Post.....

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    ReplyDelete
  2. I read a lot of blog posts and I never heard of a topic like this. You can also read my blog related to Punching dies.
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  3. i manufacturing key way milling machine

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